1q4x Summary


Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24

The structure was published by Borngraeber, S., Budny, M.J., Chiellini, G., et al., Baxter, J.D., Scanlan, T.S., and Fletterick, R.J., in 2003 in a paper entitled "Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Thyroid hormone receptor beta-1. This molecule has the UniProt identifier P10828 (THB_HUMAN)search. The sample contained 253 residues which is < 90% of the natural sequence. Out of 253 residues 237 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Thyroid hormone receptor beta-1 P10828 (209-461) (THB_HUMAN)search Homo sapienssearch < 90% 253 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10828 (209 - 461) Thyroid hormone receptor beta-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P10828) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch thyroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch