1q41 Summary


GSK-3 Beta complexed with Indirubin-3'-monoxime

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 80%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 80%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (2 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein bindingsearch ionotropic glutamate receptor bindingsearch tau-protein kinase activitysearch integrin bindingsearch protein kinase bindingsearch transferase activitysearch kinase activitysearch protein kinase A catalytic subunit bindingsearch beta-catenin bindingsearch ubiquitin protein ligase bindingsearch NF-kappaB bindingsearch tau protein bindingsearch nucleotide bindingsearch RNA polymerase II transcription factor bindingsearch p53 bindingsearch protein phosphorylationsearch phosphatidylinositol-mediated signalingsearch ER overload responsesearch hypermethylation of CpG islandsearch response to drugsearch positive regulation of protein bindingsearch positive regulation of cell-matrix adhesionsearch peptidyl-serine phosphorylationsearch organ morphogenesissearch innate immune responsesearch neurotrophin TRK receptor signaling pathwaysearch negative regulation of NFAT protein import into nucleussearch extrinsic apoptotic signaling pathway in absence of ligandsearch response to lithium ionsearch hippocampus developmentsearch positive regulation of protein catabolic processsearch rhythmic processsearch negative regulation of type B pancreatic cell developmentsearch positive regulation of Rac GTPase activitysearch axon guidancesearch cell migrationsearch canonical Wnt signaling pathwaysearch regulation of gene expression by genetic imprintingsearch cellular response to mechanical stimulussearch intracellular signal transductionsearch negative regulation of apoptotic processsearch myotube differentiationsearch positive regulation of peptidyl-serine phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch circadian rhythmsearch Wnt signaling pathwaysearch carbohydrate metabolic processsearch regulation of microtubule-based processsearch negative regulation of cardiac muscle hypertrophysearch nervous system developmentsearch establishment of cell polaritysearch multicellular organismal developmentsearch protein localization to microtubulesearch negative regulation of protein bindingsearch negative regulation of signal transductionsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch phosphorylationsearch myoblast fusionsearch establishment or maintenance of cell polaritysearch negative regulation of protein complex assemblysearch positive regulation of protein complex assemblysearch positive regulation of apoptotic processsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to interleukin-3search cell differentiationsearch positive regulation of protein export from nucleussearch positive regulation of peptidyl-threonine phosphorylationsearch glycogen metabolic processsearch epidermal growth factor receptor signaling pathwaysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of dendrite morphogenesissearch protein export from nucleussearch Fc-epsilon receptor signaling pathwaysearch negative regulation of glycogen biosynthetic processsearch positive regulation of stem cell differentiationsearch negative regulation of MAP kinase activitysearch epithelial to mesenchymal transitionsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch superior temporal gyrus developmentsearch fat cell differentiationsearch axonogenesissearch regulation of neuronal synaptic plasticitysearch re-entry into mitotic cell cyclesearch protein complexsearch cytosolsearch beta-catenin destruction complexsearch membrane-bounded organellesearch cytoplasmsearch plasma membranesearch membranesearch ribonucleoprotein complexsearch dendritic spinesearch growth conesearch dendritic shaftsearch nucleussearch centrosomesearch neuronal cell bodysearch membrane raftsearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch