1q41 Summary


GSK-3 Beta complexed with Indirubin-3'-monoxime

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 80%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 80%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (2 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) nucleotide bindingsearch RNA polymerase II transcription factor bindingsearch p53 bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch integrin bindingsearch protein bindingsearch ATP bindingsearch beta-catenin bindingsearch kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase bindingsearch ubiquitin protein ligase bindingsearch protein kinase A catalytic subunit bindingsearch ionotropic glutamate receptor bindingsearch tau protein bindingsearch tau-protein kinase activitysearch NF-kappaB bindingsearch re-entry into mitotic cell cyclesearch epithelial to mesenchymal transitionsearch positive regulation of cell-matrix adhesionsearch carbohydrate metabolic processsearch glycogen metabolic processsearch regulation of gene expression by genetic imprintingsearch protein phosphorylationsearch protein export from nucleussearch ER overload responsesearch establishment or maintenance of cell polaritysearch epidermal growth factor receptor signaling pathwaysearch multicellular organismal developmentsearch nervous system developmentsearch axonogenesissearch axon guidancesearch myoblast fusionsearch circadian rhythmsearch fibroblast growth factor receptor signaling pathwaysearch organ morphogenesissearch negative regulation of signal transductionsearch response to lithium ionsearch negative regulation of cardiac muscle hypertrophysearch positive regulation of peptidyl-threonine phosphorylationsearch regulation of neuron projection developmentsearch negative regulation of neuron projection developmentsearch negative regulation of neuron maturationsearch myotube differentiationsearch Wnt signaling pathwaysearch phosphorylationsearch cell migrationsearch peptidyl-serine phosphorylationsearch hippocampus developmentsearch establishment of cell polaritysearch cell differentiationsearch negative regulation of protein complex assemblysearch positive regulation of protein complex assemblysearch negative regulation of protein bindingsearch positive regulation of protein bindingsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch regulation of microtubule-based processsearch positive regulation of peptidyl-serine phosphorylationsearch cellular response to heatsearch protein localization to microtubulesearch intracellular signal transductionsearch cellular response to interleukin-3search Fc-epsilon receptor signaling pathwaysearch response to drugsearch positive regulation of apoptotic processsearch negative regulation of apoptotic processsearch negative regulation of MAP kinase activitysearch hypermethylation of CpG islandsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch innate immune responsesearch fat cell differentiationsearch negative regulation of glycogen biosynthetic processsearch positive regulation of protein catabolic processsearch positive regulation of axon extensionsearch positive regulation of transcription from RNA polymerase II promotersearch protein autophosphorylationsearch positive regulation of protein export from nucleussearch neurotrophin TRK receptor signaling pathwaysearch phosphatidylinositol-mediated signalingsearch regulation of neuronal synaptic plasticitysearch rhythmic processsearch negative regulation of dendrite morphogenesissearch negative regulation of NFAT protein import into nucleussearch canonical Wnt signaling pathwaysearch superior temporal gyrus developmentsearch cellular response to mechanical stimulussearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of canonical Wnt signaling pathwaysearch extrinsic apoptotic signaling pathway in absence of ligandsearch regulation of cellular response to heatsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch negative regulation of type B pancreatic cell developmentsearch negative regulation of glycogen (starch) synthase activitysearch positive regulation of stem cell differentiationsearch nucleussearch nucleoplasmsearch cytoplasmsearch centrosomesearch cytosolsearch plasma membranesearch membranesearch growth conesearch ribonucleoprotein complexsearch beta-catenin destruction complexsearch neuronal cell bodysearch dendritic spinesearch dendritic shaftsearch membrane-bounded organellesearch protein complexsearch cell bodysearch membrane raftsearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch