1q3w Summary

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GSK-3 Beta complexed with Alsterpaullone

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 81%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (2 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch negative regulation of glycogen biosynthetic processsearch Wnt signaling pathwaysearch circadian rhythmsearch epithelial to mesenchymal transitionsearch carbohydrate metabolic processsearch axon guidancesearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch canonical Wnt signaling pathwaysearch positive regulation of Rac GTPase activitysearch regulation of gene expression by genetic imprintingsearch peptidyl-serine phosphorylationsearch negative regulation of signal transductionsearch response to lithium ionsearch regulation of microtubule-based processsearch establishment or maintenance of cell polaritysearch cell differentiationsearch positive regulation of stem cell differentiationsearch positive regulation of cell-matrix adhesionsearch organ morphogenesissearch glycogen metabolic processsearch negative regulation of NFAT protein import into nucleussearch positive regulation of transcription from RNA polymerase II promotersearch ER overload responsesearch positive regulation of protein catabolic processsearch cell migrationsearch phosphorylationsearch fat cell differentiationsearch hypermethylation of CpG islandsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of protein export from nucleussearch cellular response to mechanical stimulussearch positive regulation of peptidyl-serine phosphorylationsearch protein export from nucleussearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of type B pancreatic cell developmentsearch negative regulation of cardiac muscle hypertrophysearch intracellular signal transductionsearch myoblast fusionsearch negative regulation of protein complex assemblysearch hippocampus developmentsearch Fc-epsilon receptor signaling pathwaysearch positive regulation of apoptotic processsearch protein localization to microtubulesearch negative regulation of apoptotic processsearch response to drugsearch regulation of neuronal synaptic plasticitysearch multicellular organismal developmentsearch phosphatidylinositol-mediated signalingsearch axonogenesissearch rhythmic processsearch cellular response to interleukin-3search re-entry into mitotic cell cyclesearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch innate immune responsesearch negative regulation of glycogen (starch) synthase activitysearch negative regulation of protein bindingsearch negative regulation of MAP kinase activitysearch positive regulation of protein bindingsearch nervous system developmentsearch positive regulation of protein complex assemblysearch positive regulation of peptidyl-threonine phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch negative regulation of dendrite morphogenesissearch epidermal growth factor receptor signaling pathwaysearch establishment of cell polaritysearch myotube differentiationsearch superior temporal gyrus developmentsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ubiquitin protein ligase bindingsearch protein bindingsearch tau-protein kinase activitysearch protein kinase bindingsearch ATP bindingsearch RNA polymerase II transcription factor bindingsearch kinase activitysearch beta-catenin bindingsearch ionotropic glutamate receptor bindingsearch transferase activitysearch protein kinase A catalytic subunit bindingsearch tau protein bindingsearch NF-kappaB bindingsearch integrin bindingsearch nucleotide bindingsearch p53 bindingsearch beta-catenin destruction complexsearch cytosolsearch cytoplasmsearch membranesearch centrosomesearch ribonucleoprotein complexsearch membrane-bounded organellesearch neuronal cell bodysearch nucleussearch dendritic shaftsearch growth conesearch dendritic spinesearch protein complexsearch membrane raftsearch plasma membranesearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch