1q3d Summary

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GSK-3 Beta complexed with Staurosporine

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 79%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 79%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (2 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch phosphorylationsearch positive regulation of protein catabolic processsearch glycogen metabolic processsearch response to lithium ionsearch hippocampus developmentsearch regulation of neuronal synaptic plasticitysearch fat cell differentiationsearch ER overload responsesearch myotube differentiationsearch protein localization to microtubulesearch hypermethylation of CpG islandsearch epidermal growth factor receptor signaling pathwaysearch negative regulation of NFAT protein import into nucleussearch peptidyl-serine phosphorylationsearch positive regulation of peptidyl-threonine phosphorylationsearch positive regulation of protein bindingsearch positive regulation of apoptotic processsearch positive regulation of protein complex assemblysearch nervous system developmentsearch negative regulation of glycogen (starch) synthase activitysearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch canonical Wnt signaling pathwaysearch cell differentiationsearch regulation of cellular response to heatsearch negative regulation of protein complex assemblysearch cellular response to heatsearch negative regulation of glycogen biosynthetic processsearch axonogenesissearch circadian rhythmsearch superior temporal gyrus developmentsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch negative regulation of type B pancreatic cell developmentsearch regulation of microtubule-based processsearch establishment or maintenance of cell polaritysearch regulation of gene expression by genetic imprintingsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch positive regulation of peptidyl-serine phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch negative regulation of protein bindingsearch extrinsic apoptotic signaling pathway in absence of ligandsearch epithelial to mesenchymal transitionsearch negative regulation of neuron maturationsearch negative regulation of MAP kinase activitysearch carbohydrate metabolic processsearch protein export from nucleussearch axon guidancesearch positive regulation of transcription from RNA polymerase II promotersearch protein autophosphorylationsearch re-entry into mitotic cell cyclesearch cellular response to mechanical stimulussearch cellular response to interleukin-3search organ morphogenesissearch response to drugsearch multicellular organismal developmentsearch rhythmic processsearch establishment of cell polaritysearch negative regulation of apoptotic processsearch phosphatidylinositol-mediated signalingsearch Wnt signaling pathwaysearch positive regulation of protein export from nucleussearch neurotrophin TRK receptor signaling pathwaysearch myoblast fusionsearch regulation of neuron projection developmentsearch intracellular signal transductionsearch positive regulation of stem cell differentiationsearch positive regulation of canonical Wnt signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch negative regulation of dendrite morphogenesissearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of neuron projection developmentsearch innate immune responsesearch negative regulation of cardiac muscle hypertrophysearch positive regulation of cell-matrix adhesionsearch cell migrationsearch negative regulation of signal transductionsearch positive regulation of axon extensionsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch ATP bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch tau-protein kinase activitysearch protein kinase A catalytic subunit bindingsearch p53 bindingsearch beta-catenin bindingsearch protein kinase bindingsearch protein kinase activitysearch ubiquitin protein ligase bindingsearch NF-kappaB bindingsearch nucleotide bindingsearch RNA polymerase II transcription factor bindingsearch integrin bindingsearch tau protein bindingsearch transferase activitysearch ionotropic glutamate receptor bindingsearch plasma membranesearch cytoplasmsearch membranesearch cytosolsearch nucleussearch beta-catenin destruction complexsearch protein complexsearch neuronal cell bodysearch cell bodysearch dendritic shaftsearch centrosomesearch dendritic spinesearch ribonucleoprotein complexsearch membrane raftsearch membrane-bounded organellesearch growth conesearch nucleoplasmsearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch