1q3d Summary

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GSK-3 Beta complexed with Staurosporine

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 79%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 79%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (2 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) axonogenesissearch peptidyl-serine phosphorylationsearch axon guidancesearch organ morphogenesissearch positive regulation of protein bindingsearch extrinsic apoptotic signaling pathway in absence of ligandsearch protein phosphorylationsearch Wnt signaling pathwaysearch cellular response to interleukin-3search positive regulation of protein export from nucleussearch neurotrophin TRK receptor signaling pathwaysearch regulation of microtubule-based processsearch response to lithium ionsearch positive regulation of stem cell differentiationsearch response to drugsearch negative regulation of dendrite morphogenesissearch negative regulation of neuron projection developmentsearch intracellular signal transductionsearch ER overload responsesearch negative regulation of apoptotic processsearch phosphatidylinositol-mediated signalingsearch negative regulation of signal transductionsearch establishment of cell polaritysearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch myotube differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch circadian rhythmsearch positive regulation of peptidyl-threonine phosphorylationsearch canonical Wnt signaling pathwaysearch positive regulation of peptidyl-serine phosphorylationsearch fat cell differentiationsearch positive regulation of canonical Wnt signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch carbohydrate metabolic processsearch re-entry into mitotic cell cyclesearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of cell-matrix adhesionsearch innate immune responsesearch glycogen metabolic processsearch positive regulation of protein catabolic processsearch regulation of cellular response to heatsearch cellular response to mechanical stimulussearch negative regulation of protein complex assemblysearch cellular response to heatsearch cell differentiationsearch establishment or maintenance of cell polaritysearch protein localization to microtubulesearch negative regulation of cardiac muscle hypertrophysearch regulation of neuronal synaptic plasticitysearch positive regulation of protein complex assemblysearch multicellular organismal developmentsearch negative regulation of glycogen (starch) synthase activitysearch hippocampus developmentsearch phosphorylationsearch negative regulation of NFAT protein import into nucleussearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch rhythmic processsearch negative regulation of MAP kinase activitysearch epidermal growth factor receptor signaling pathwaysearch regulation of gene expression by genetic imprintingsearch hypermethylation of CpG islandsearch nervous system developmentsearch epithelial to mesenchymal transitionsearch regulation of neuron projection developmentsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of apoptotic processsearch myoblast fusionsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of protein bindingsearch negative regulation of glycogen biosynthetic processsearch positive regulation of Rac GTPase activitysearch cell migrationsearch protein export from nucleussearch superior temporal gyrus developmentsearch negative regulation of type B pancreatic cell developmentsearch negative regulation of neuron maturationsearch positive regulation of axon extensionsearch protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch tau-protein kinase activitysearch beta-catenin bindingsearch RNA polymerase II transcription factor bindingsearch integrin bindingsearch NF-kappaB bindingsearch transferase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch tau protein bindingsearch p53 bindingsearch protein kinase bindingsearch ionotropic glutamate receptor bindingsearch protein kinase A catalytic subunit bindingsearch ubiquitin protein ligase bindingsearch beta-catenin destruction complexsearch cytosolsearch cytoplasmsearch centrosomesearch cell bodysearch ribonucleoprotein complexsearch membrane-bounded organellesearch nucleoplasmsearch nucleussearch dendritic spinesearch membrane raftsearch perinuclear region of cytoplasmsearch membranesearch growth conesearch plasma membranesearch protein complexsearch dendritic shaftsearch neuronal cell bodysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch