1q3d Summary


GSK-3 Beta complexed with Staurosporine

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 79%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (2-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 424 79%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (2 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) myoblast fusionsearch positive regulation of protein bindingsearch organ morphogenesissearch negative regulation of apoptotic processsearch response to drugsearch Wnt signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of stem cell differentiationsearch protein phosphorylationsearch response to lithium ionsearch protein export from nucleussearch epidermal growth factor receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch regulation of neuronal synaptic plasticitysearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch axon guidancesearch protein localization to microtubulesearch canonical Wnt signaling pathwaysearch cellular response to interleukin-3search ER overload responsesearch cell differentiationsearch cellular response to mechanical stimulussearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch regulation of gene expression by genetic imprintingsearch cell migrationsearch positive regulation of cell-matrix adhesionsearch positive regulation of protein catabolic processsearch multicellular organismal developmentsearch glycogen metabolic processsearch negative regulation of MAP kinase activitysearch negative regulation of glycogen (starch) synthase activitysearch positive regulation of apoptotic processsearch re-entry into mitotic cell cyclesearch negative regulation of cardiac muscle hypertrophysearch hippocampus developmentsearch Fc-epsilon receptor signaling pathwaysearch positive regulation of protein complex assemblysearch innate immune responsesearch negative regulation of protein complex assemblysearch myotube differentiationsearch establishment or maintenance of cell polaritysearch peptidyl-serine phosphorylationsearch negative regulation of NFAT protein import into nucleussearch negative regulation of neuron projection developmentsearch epithelial to mesenchymal transitionsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of protein bindingsearch phosphatidylinositol-mediated signalingsearch negative regulation of glycogen biosynthetic processsearch positive regulation of Rac GTPase activitysearch positive regulation of peptidyl-serine phosphorylationsearch circadian rhythmsearch rhythmic processsearch negative regulation of neuron maturationsearch phosphorylationsearch negative regulation of signal transductionsearch superior temporal gyrus developmentsearch neurotrophin TRK receptor signaling pathwaysearch negative regulation of type B pancreatic cell developmentsearch negative regulation of dendrite morphogenesissearch axonogenesissearch hypermethylation of CpG islandsearch extrinsic apoptotic signaling pathway in absence of ligandsearch intracellular signal transductionsearch regulation of microtubule-based processsearch fat cell differentiationsearch nervous system developmentsearch positive regulation of protein export from nucleussearch carbohydrate metabolic processsearch positive regulation of peptidyl-threonine phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch establishment of cell polaritysearch protein bindingsearch tau-protein kinase activitysearch protein serine/threonine kinase activitysearch ionotropic glutamate receptor bindingsearch kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase bindingsearch beta-catenin bindingsearch p53 bindingsearch tau protein bindingsearch protein kinase A catalytic subunit bindingsearch nucleotide bindingsearch transferase activitysearch integrin bindingsearch ubiquitin protein ligase bindingsearch RNA polymerase II transcription factor bindingsearch NF-kappaB bindingsearch membranesearch cytosolsearch dendritic spinesearch ribonucleoprotein complexsearch membrane raftsearch growth conesearch dendritic shaftsearch nucleussearch cytoplasmsearch plasma membranesearch beta-catenin destruction complexsearch perinuclear region of cytoplasmsearch protein complexsearch centrosomesearch neuronal cell bodysearch cell bodysearch membrane-bounded organellesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch