1q2u Summary


PDB entry 1q2u (supersedes 1ps4)

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

The structure was published by Huai, Q., Sun, Y., Wang, H., et al., Li, L., Robinson, H., and Ke, H., in 2003 in a paper entitled "Crystal structure of DJ-1/RS and implication on familial Parkinson's disease" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RNA-binding protein regulatory subunit. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 189 residues which is 100% of the natural sequence. Out of 189 residues 188 were observed and are deposited in the PDB.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RNA-binding protein regulatory subunit Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) RNA-binding protein regulatory subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q99497) DJ-1/PfpIsearch Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q99497) regulation of neuron apoptotic processsearch negative regulation of neuron apoptotic processsearch cellular response to oxidative stresssearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of extrinsic apoptotic signaling pathwaysearch glyoxal catabolic processsearch positive regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of superoxide dismutase activitysearch negative regulation of protein sumoylationsearch negative regulation of protein kinase activitysearch Ras protein signal transductionsearch mitochondrion organizationsearch negative regulation of hydrogen peroxide-induced neuron deathsearch regulation of inflammatory responsesearch positive regulation of protein localization to nucleussearch cellular response to glyoxalsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch negative regulation of protein acetylationsearch hydrogen peroxide metabolic processsearch autophagysearch negative regulation of death-inducing signaling complex assemblysearch positive regulation of dopamine biosynthetic processsearch negative regulation of protein bindingsearch methylglyoxal catabolic process to D-lactatesearch negative regulation of protein ubiquitinationsearch membrane hyperpolarizationsearch cellular response to hydrogen peroxidesearch negative regulation of cell deathsearch negative regulation of protein export from nucleussearch oxidation-reduction processsearch inflammatory responsesearch positive regulation of L-dopa biosynthetic processsearch synaptic transmission, dopaminergicsearch positive regulation of androgen receptor activitysearch negative regulation of hydrogen peroxide-induced cell deathsearch protein stabilizationsearch negative regulation of apoptotic processsearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of proteasomal ubiquitin-dependent protein catabolic processsearch negative regulation of gene expressionsearch positive regulation of protein kinase B signalingsearch negative regulation of ubiquitin-specific protease activitysearch cellular response to reactive oxygen speciessearch positive regulation of tyrosine 3-monooxygenase activitysearch positive regulation of transcription regulatory region DNA bindingsearch proteolysissearch negative regulation of protein phosphorylationsearch regulation of TRAIL receptor biosynthetic processsearch regulation of androgen receptor signaling pathwaysearch response to hydrogen peroxidesearch negative regulation of neuron deathsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch single fertilizationsearch dopamine uptake involved in synaptic transmissionsearch positive regulation of interleukin-8 productionsearch negative regulation of ubiquitin-protein transferase activitysearch positive regulation of pyrroline-5-carboxylate reductase activitysearch positive regulation of oxidative phosphorylation uncoupler activitysearch regulation of mitochondrial membrane potentialsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch activation of protein kinase B activitysearch positive regulation of gene expressionsearch positive regulation of protein homodimerization activitysearch negative regulation of protein K48-linked deubiquitinationsearch adult locomotory behaviorsearch lactate biosynthetic processsearch membrane depolarizationsearch negative regulation of oxidative stress-induced cell deathsearch regulation of fibril organizationsearch glycolate biosynthetic processsearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch positive regulation of L-dopa decarboxylase activitysearch peptidase activitysearch enzyme bindingsearch receptor bindingsearch protein bindingsearch mRNA bindingsearch RNA bindingsearch peroxiredoxin activitysearch single-stranded DNA bindingsearch glyoxalase (glycolic acid-forming) activitysearch ubiquitin-specific protease bindingsearch glyoxalase III activitysearch identical protein bindingsearch superoxide dismutase copper chaperone activitysearch double-stranded DNA bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch tyrosine 3-monooxygenase activator activitysearch transcription factor bindingsearch small protein activating enzyme bindingsearch cytokine bindingsearch transcription coactivator activitysearch scaffold protein bindingsearch androgen receptor bindingsearch cuprous ion bindingsearch core promoter bindingsearch hydrolase activitysearch protein homodimerization activitysearch L-dopa decarboxylase activator activitysearch repressing transcription factor bindingsearch peroxidase activitysearch small protein conjugating enzyme bindingsearch cupric ion bindingsearch nucleussearch mitochondrionsearch cytoplasmsearch cytosolsearch membranesearch chromatinsearch extracellular vesicular exosomesearch membrane raftsearch plasma membranesearch axonsearch mitochondrial respiratory chain complex Isearch PML bodysearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch