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PDBe Entry: 1q2q 
Enterobacter cloacae GC1 class C beta-lactamase complexed with penem WAY185229
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HYDROLASE
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X-RAY DIFFRACTION
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Resolution: 1.4 Å, R-factor: 14.5%, Free R-factor: 20.9%, Spacegroup: P 21 21 2
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14/09/2004, deposition: 25/07/2003, last revision: 24/02/2009
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Nukaga, M.; Venkatesan, A.M.; Mansour, T.S.; Hujer, A.; Bonomo, R.A.; Knox, J.R.
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Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates
J.MED.CHEM. vol:47, pag:6556-6568 (2004) [PubMed ID 15588091 ]
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hydrolase, inhibition, beta-lactam antibiotics, drug design
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3.5.2.6 ExPASy BRENDA (A)
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Enterobacter cloacae 550(A)
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Class C beta-lactamase precursor (EC 3.5.2.6) Q59401 (A)
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A
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1q2p, 1shv, 1ong, 1onh
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| A |
class C beta-lactamase |
Protein |
Q59401 (Q59401_ENTCL)
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363 |
98% |
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| A |
(6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID |
WY2
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| A |
GLYCEROL |
GOL
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