1q0n Summary

pdbe.org/1q0n
spacer

PDB entry 1q0n (supersedes 1eqo)

CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE FROM E. COLI WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.25 ANGSTROM RESOLUTION

The structure was published by Blaszczyk, J., Shi, G., Yan, H., and Ji, X., in 2000 in a paper entitled "Catalytic Center Assembly of Hppk as Revealed by the Crystal Structure of a Ternary Complex at 1.25 A Resolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.25 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. This molecule has the UniProt identifier P26281 (HPPK_ECOLI)search. The sample contained 158 residues which is 99% of the natural sequence. Out of 158 residues 158 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase P26281 (2-159) (HPPK_ECOLI)search Escherichia coli K-12search 96% 158 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P26281 (2 - 159) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P26281) 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPKsearch Alpha-Beta Plaitssearch PF01288: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)search

Chain ID Molecular function (GO) Biological process (GO)
A (P26281) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activitysearch ATP bindingsearch magnesium ion bindingsearch nucleotide bindingsearch kinase activitysearch transferase activitysearch folic acid biosynthetic processsearch phosphorylationsearch tetrahydrofolate biosynthetic processsearch folic acid-containing compound biosynthetic processsearch

Chain InterPro annotation
A 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPKsearch