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PDBe Entry: 1pzy 
W314A-BETA1,4-GALACTOSYLTRANSFERASE-I COMPLEXED WITH ALPHA-LACTALBUMIN IN THE PRESENCE OF N-ACETYLGLUCOSAMINE, UDP AND MANGANESE
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TRANSFERASE ACTIVATOR/TRANSFERASE
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X-RAY DIFFRACTION
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Resolution: 2.3 Å, R-factor: 20.71%, Free R-factor: 25.3%, Spacegroup: P 1 21 1
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02/09/2003, deposition: 14/07/2003, last revision: 24/02/2009
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Ramasamy, V.; Ramakrishnan, B.; Boeggeman, E.; Qasba, P.K.
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The Role of Tryptophan 314 in the Conformational Changes of beta 1,4-Galactosyltransferase-I
J.MOL.BIOL. vol:331, pag:1065-1076 (2003) [PubMed ID 12927542 ]
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Beta1, 4-Galactosyltransferase-I Tryptophan Mutant, Flexible loop Conformation, Protease Digetion, Substrate Binding, Catalytic Mechanism, TRANSFERASE ACTIVATOR/TRANSFERASE COMPLEX
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2.4.1.22 ExPASy BRENDA 2.4.1.38 ExPASy BRENDA 2.4.1.90 ExPASy BRENDA (B D)
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Mus musculus(house mouse) 10090(A C),Bos taurus(cattle) 9913(B D)
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Alpha-lactalbumin precursor (Lactose synthase B protein) P29752 (A C)
Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)] [Contains: Processed beta-1,4-galactosyltransferase 1] P08037 (B D)
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A, B, C, D
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1nmm, 1nkh
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| A, C |
ALPHA-LACTALBUMIN |
Protein |
P29752 (LALBA_MOUSE)
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123 |
100% |
| B, D |
BETA-1,4-GALACTOSYLTRANSFERASE |
Protein |
P08037 (B4GT1_BOVIN)
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286 |
94% |
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| B, D |
SUGAR (N-ACETYL-D-GLUCOSAMINE) |
NAG
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| A, C |
CALCIUM ION |
CA
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| B, D |
MANGANESE (II) ION |
MN
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| B, D |
URIDINE-5'-DIPHOSPHATE |
UDP
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