1pyy Summary


Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution

The structure was published by Chesnel, L., Pernot, L., Lemaire, D., et al., Dideberg, O., Vernet, T., and Zapun, A., in 2003 in a paper entitled "The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.42 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Penicillin-binding protein 2X. This molecule has the UniProt identifier P59676 (PBPX_STRR6)search. The sample contained 702 residues which is 94% of the natural sequence. Out of 702 residues 606 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Penicillin-binding protein 2X P59676 (49-750) (PBPX_STRR6)search Streptococcus pneumoniae R6search 94% 702 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P59676 (49 - 750) Penicillin-binding protein 2X Streptococcus pneumoniae R6

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P59676) Penicillin-binding protein 2x (pbp-2x), c-terminal domainsearch, Penicillin binding protein dimerisation domainsearch, beta-Lactamase/D-ala carboxypeptidasesearch PF00905: Penicillin binding protein transpeptidase domainsearch, PF03717: Penicillin-binding Protein dimerisation domainsearch, PF03793: PASTA domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P59676) penicillin bindingsearch peptidoglycan biosynthetic processsearch cell cyclesearch cell divisionsearch regulation of cell shapesearch response to antibioticsearch integral component of membranesearch plasma membranesearch membranesearch

Chain InterPro annotation
A Penicillin-binding protein, transpeptidasesearch Penicillin-binding protein, dimerisation domainsearch PASTA domainsearch Beta-lactamase/transpeptidase-likesearch