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Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution

Source organism: Streptococcus pneumoniae R6
Biochemical function: penicillin binding
Biological process: cell wall organization
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03793
Domain description: PASTA domain
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 1 copy of Pfam domain PF03793 (PASTA domain) in Penicillin-binding protein 2X. Showing 1 copy in chain A.

PF00905
Domain description: Penicillin binding protein transpeptidase domain
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 1 copy of Pfam domain PF00905 (Penicillin binding protein transpeptidase domain) in Penicillin-binding protein 2X. Showing 1 copy in chain A.

PF03717
Domain description: Penicillin-binding Protein dimerisation domain
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 1 copy of Pfam domain PF03717 (Penicillin-binding Protein dimerisation domain) in Penicillin-binding protein 2X. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005543
Domain description: PASTA domain
Occurring in:
  1. Penicillin-binding protein 2X
IPR012338
Domain description: Beta-lactamase/transpeptidase-like
Occurring in:
  1. Penicillin-binding protein 2X
IPR001460
Domain description: Penicillin-binding protein, transpeptidase
Occurring in:
  1. Penicillin-binding protein 2X
IPR005311
Domain description: Penicillin-binding protein, dimerisation domain
Occurring in:
  1. Penicillin-binding protein 2X
IPR036138
Domain description: Penicillin-binding protein, dimerisation domain superfamily
Occurring in:
  1. Penicillin-binding protein 2X

Structure domains

CATH CATH domains
3.90.1310.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Penicillin-binding protein 2a (Domain 2)
Homology: Penicillin-binding protein 2a (Domain 2)
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 1 copy of CATH domain 3.90.1310.10 (Penicillin-binding protein 2a (Domain 2)) in Penicillin-binding protein 2X. Showing 1 copy in chain A.
3.40.710.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Beta-lactamase
Homology: DD-peptidase/beta-lactamase superfamily
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 1 copy of CATH domain 3.40.710.10 (Beta-lactamase) in Penicillin-binding protein 2X. Showing 1 copy in chain A.
SCOP SCOP annotations
54185
Class: Alpha and beta proteins (a+b)
Fold: Penicillin-binding protein 2x (pbp-2x), c-terminal domain
Superfamily: Penicillin-binding protein 2x (pbp-2x), c-terminal domain
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 2 copies of SCOP domain 54185 (Penicillin-binding protein 2x (pbp-2x), c-terminal domain) in Penicillin-binding protein 2X. Showing 2 copies in chain A.
56602
Class: Multi-domain proteins (alpha and beta)
Fold: beta-lactamase/transpeptidase-like
Superfamily: beta-lactamase/transpeptidase-like
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 1 copy of SCOP domain 56602 (beta-Lactamase/D-ala carboxypeptidase) in Penicillin-binding protein 2X. Showing 1 copy in chain A.
56520
Class: Alpha and beta proteins (a+b)
Fold: Penicillin binding protein dimerisation domain
Superfamily: Penicillin binding protein dimerisation domain
Occurring in:
  1. Penicillin-binding protein 2X
The deposited structure of PDB entry 1pyy contains 1 copy of SCOP domain 56520 (Penicillin binding protein dimerisation domain) in Penicillin-binding protein 2X. Showing 1 copy in chain A.

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