1pyx Summary

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GSK-3 Beta complexed with AMP-PNP

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 422 81%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 422 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) ATP bindingsearch protein kinase bindingsearch protein bindingsearch p53 bindingsearch kinase activitysearch tau protein bindingsearch beta-catenin bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch NF-kappaB bindingsearch nucleotide bindingsearch ionotropic glutamate receptor bindingsearch tau-protein kinase activitysearch protein kinase activitysearch ubiquitin protein ligase bindingsearch integrin bindingsearch protein kinase A catalytic subunit bindingsearch transferase activitysearch RNA polymerase II transcription factor bindingsearch phosphatidylinositol-mediated signalingsearch regulation of microtubule-based processsearch protein localization to microtubulesearch protein phosphorylationsearch positive regulation of protein bindingsearch glycogen metabolic processsearch hippocampus developmentsearch regulation of neuronal synaptic plasticitysearch negative regulation of cardiac muscle hypertrophysearch epithelial to mesenchymal transitionsearch epidermal growth factor receptor signaling pathwaysearch negative regulation of neuron projection developmentsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch phosphorylationsearch Wnt signaling pathwaysearch organ morphogenesissearch negative regulation of glycogen biosynthetic processsearch superior temporal gyrus developmentsearch negative regulation of apoptotic processsearch positive regulation of apoptotic processsearch re-entry into mitotic cell cyclesearch negative regulation of glycogen (starch) synthase activitysearch positive regulation of protein complex assemblysearch negative regulation of MAP kinase activitysearch cellular response to interleukin-3search axon guidancesearch neurotrophin TRK receptor signaling pathwaysearch rhythmic processsearch innate immune responsesearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch nervous system developmentsearch response to drugsearch negative regulation of signal transductionsearch canonical Wnt signaling pathwaysearch ER overload responsesearch positive regulation of cell-matrix adhesionsearch negative regulation of NFAT protein import into nucleussearch carbohydrate metabolic processsearch fibroblast growth factor receptor signaling pathwaysearch establishment or maintenance of cell polaritysearch circadian rhythmsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of neuron maturationsearch myoblast fusionsearch peptidyl-serine phosphorylationsearch hypermethylation of CpG islandsearch cell migrationsearch cellular response to mechanical stimulussearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of type B pancreatic cell developmentsearch negative regulation of protein complex assemblysearch intracellular signal transductionsearch multicellular organismal developmentsearch positive regulation of protein catabolic processsearch negative regulation of canonical Wnt signaling pathwaysearch fat cell differentiationsearch protein export from nucleussearch negative regulation of dendrite morphogenesissearch myotube differentiationsearch positive regulation of protein export from nucleussearch response to lithium ionsearch axonogenesissearch cell differentiationsearch negative regulation of protein bindingsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of gene expression by genetic imprintingsearch establishment of cell polaritysearch positive regulation of Rac GTPase activitysearch positive regulation of stem cell differentiationsearch cytosolsearch cytoplasmsearch membrane raftsearch cell bodysearch beta-catenin destruction complexsearch neuronal cell bodysearch dendritic spinesearch protein complexsearch plasma membranesearch growth conesearch nucleussearch membranesearch nucleoplasmsearch membrane-bounded organellesearch perinuclear region of cytoplasmsearch centrosomesearch ribonucleoprotein complexsearch dendritic shaftsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch