1pyx Summary

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GSK-3 Beta complexed with AMP-PNP

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 422 81%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 422 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) positive regulation of apoptotic processsearch negative regulation of signal transductionsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of Rac GTPase activitysearch peptidyl-serine phosphorylationsearch positive regulation of stem cell differentiationsearch positive regulation of protein bindingsearch negative regulation of protein bindingsearch ER overload responsesearch positive regulation of protein export from nucleussearch cellular response to mechanical stimulussearch negative regulation of cardiac muscle hypertrophysearch axonogenesissearch protein phosphorylationsearch phosphatidylinositol-mediated signalingsearch glycogen metabolic processsearch positive regulation of protein complex assemblysearch negative regulation of glycogen (starch) synthase activitysearch establishment of cell polaritysearch Wnt signaling pathwaysearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch re-entry into mitotic cell cyclesearch cell migrationsearch circadian rhythmsearch multicellular organismal developmentsearch nervous system developmentsearch protein localization to microtubulesearch superior temporal gyrus developmentsearch negative regulation of glycogen biosynthetic processsearch negative regulation of apoptotic processsearch protein export from nucleussearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to interleukin-3search hippocampus developmentsearch epithelial to mesenchymal transitionsearch canonical Wnt signaling pathwaysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch epidermal growth factor receptor signaling pathwaysearch phosphorylationsearch myotube differentiationsearch organ morphogenesissearch regulation of microtubule-based processsearch positive regulation of cell-matrix adhesionsearch negative regulation of MAP kinase activitysearch negative regulation of neuron projection developmentsearch negative regulation of NFAT protein import into nucleussearch fibroblast growth factor receptor signaling pathwaysearch establishment or maintenance of cell polaritysearch regulation of neuronal synaptic plasticitysearch fat cell differentiationsearch carbohydrate metabolic processsearch innate immune responsesearch response to lithium ionsearch positive regulation of peptidyl-serine phosphorylationsearch response to drugsearch hypermethylation of CpG islandsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch axon guidancesearch positive regulation of protein catabolic processsearch negative regulation of neuron maturationsearch negative regulation of dendrite morphogenesissearch negative regulation of canonical Wnt signaling pathwaysearch cell differentiationsearch negative regulation of protein complex assemblysearch myoblast fusionsearch positive regulation of transcription from RNA polymerase II promotersearch intracellular signal transductionsearch negative regulation of type B pancreatic cell developmentsearch rhythmic processsearch regulation of gene expression by genetic imprintingsearch tau-protein kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch RNA polymerase II transcription factor bindingsearch nucleotide bindingsearch kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch integrin bindingsearch NF-kappaB bindingsearch p53 bindingsearch ionotropic glutamate receptor bindingsearch tau protein bindingsearch beta-catenin bindingsearch protein kinase bindingsearch transferase activitysearch ubiquitin protein ligase bindingsearch protein kinase A catalytic subunit bindingsearch cell bodysearch cytosolsearch centrosomesearch cytoplasmsearch membrane raftsearch membranesearch beta-catenin destruction complexsearch nucleussearch plasma membranesearch dendritic shaftsearch growth conesearch neuronal cell bodysearch protein complexsearch dendritic spinesearch ribonucleoprotein complexsearch perinuclear region of cytoplasmsearch membrane-bounded organellesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch