1pyx Summary

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GSK-3 Beta complexed with AMP-PNP

The structure was published by Bertrand, J.A., Thieffine, S., Vulpetti, A., et al., Knapp, S., Kalisz, H.M., and Flocco, M., in 2003 in a paper entitled "Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 422 81%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 422 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P49841) neuronal cell bodysearch cytoplasmsearch plasma membranesearch dendritic spinesearch cytosolsearch beta-catenin destruction complexsearch cell bodysearch membranesearch protein complexsearch nucleussearch membrane raftsearch growth conesearch membrane-bounded organellesearch perinuclear region of cytoplasmsearch dendritic shaftsearch centrosomesearch ribonucleoprotein complexsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch regulation of gene expression by genetic imprintingsearch phosphatidylinositol-mediated signalingsearch myotube differentiationsearch protein phosphorylationsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch ER overload responsesearch positive regulation of stem cell differentiationsearch phosphorylationsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch Fc-epsilon receptor signaling pathwaysearch hypermethylation of CpG islandsearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of peptidyl-threonine phosphorylationsearch positive regulation of protein complex assemblysearch glycogen metabolic processsearch superior temporal gyrus developmentsearch epidermal growth factor receptor signaling pathwaysearch negative regulation of glycogen biosynthetic processsearch extrinsic apoptotic signaling pathway in absence of ligandsearch peptidyl-serine phosphorylationsearch myoblast fusionsearch protein localization to microtubulesearch negative regulation of glycogen (starch) synthase activitysearch negative regulation of apoptotic processsearch regulation of microtubule-based processsearch negative regulation of neuron maturationsearch cell migrationsearch response to lithium ionsearch positive regulation of cell-matrix adhesionsearch canonical Wnt signaling pathwaysearch positive regulation of protein bindingsearch hippocampus developmentsearch epithelial to mesenchymal transitionsearch negative regulation of signal transductionsearch innate immune responsesearch neurotrophin TRK receptor signaling pathwaysearch negative regulation of NFAT protein import into nucleussearch positive regulation of apoptotic processsearch carbohydrate metabolic processsearch fibroblast growth factor receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch fat cell differentiationsearch rhythmic processsearch multicellular organismal developmentsearch cellular response to interleukin-3search negative regulation of protein complex assemblysearch cell differentiationsearch axon guidancesearch negative regulation of type B pancreatic cell developmentsearch cellular response to mechanical stimulussearch negative regulation of dendrite morphogenesissearch Wnt signaling pathwaysearch circadian rhythmsearch positive regulation of protein catabolic processsearch intracellular signal transductionsearch response to drugsearch establishment or maintenance of cell polaritysearch establishment of cell polaritysearch organ morphogenesissearch regulation of neuronal synaptic plasticitysearch negative regulation of protein bindingsearch negative regulation of cardiac muscle hypertrophysearch protein export from nucleussearch nervous system developmentsearch negative regulation of neuron projection developmentsearch negative regulation of MAP kinase activitysearch re-entry into mitotic cell cyclesearch positive regulation of protein export from nucleussearch axonogenesissearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of Rac GTPase activitysearch protein bindingsearch p53 bindingsearch integrin bindingsearch protein serine/threonine kinase activitysearch NF-kappaB bindingsearch tau protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch beta-catenin bindingsearch protein kinase bindingsearch ionotropic glutamate receptor bindingsearch tau-protein kinase activitysearch protein kinase activitysearch nucleotide bindingsearch ubiquitin protein ligase bindingsearch protein kinase A catalytic subunit bindingsearch transferase activitysearch ATP bindingsearch RNA polymerase II transcription factor bindingsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch