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REFINED STRUCTURE OF THE PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE FROM LACTOBACILLUS 30A

The structure was published by Gallagher, T., Rozwarski, D.A., Ernst, S.R., and Hackert, M.L., in 1993 in a paper entitled "Refined structure of the pyruvoyl-dependent histidine decarboxylase from Lactobacillus 30a." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE).

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE) P00862 (2-82) (DCHS_LACS3)search Lactobacillus sp. 30Asearch < 90% 81 100%
C PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE) P00862 (2-82) (DCHS_LACS3)search Lactobacillus sp. 30Asearch < 90% 81 100%
E PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE) P00862 (2-82) (DCHS_LACS3)search Lactobacillus sp. 30Asearch < 90% 81 100%
B PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE) P00862 (84-311) (DCHS_LACS3)search Lactobacillus sp. 30Asearch < 90% 229 100%
D PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE) P00862 (84-311) (DCHS_LACS3)search Lactobacillus sp. 30Asearch < 90% 229 100%
F PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE) P00862 (84-311) (DCHS_LACS3)search Lactobacillus sp. 30Asearch < 90% 229 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00862 (2 - 82) PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE (L-HISTIDINE CARBOXYLASE) Lactobacillus sp. 30A

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E Histidine decarboxylasesearch Pyruvoyl-Dependent Histidine Decarboxylas, subunit Asearch Histidine carboxylase PI chainsearch
B, D, F Histidine decarboxylasesearch Pyruvoyl-Dependent Histidine Decarboxylase, subunit Bsearch Histidine carboxylase PI chainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, C, E (P00862) histidine metabolic processsearch cellular amino acid metabolic processsearch histidine decarboxylase activitysearch carboxy-lyase activitysearch
B, D, F (P00862) cellular amino acid metabolic processsearch histidine metabolic processsearch carboxy-lyase activitysearch histidine decarboxylase activitysearch

Chain InterPro annotation
A, C, E Pyruvoyl-dependent histidine decarboxylase proenzymesearch Pyruvoyl-dependent histidine/arginine decarboxylasesearch Pyruvoyl-dependent histidine decarboxylase, subdomainsearch
B, D, F Pyruvoyl-dependent histidine decarboxylase proenzymesearch Pyruvoyl-dependent histidine/arginine decarboxylasesearch Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domainsearch