1pxx Summary

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CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

The structure was published by Rowlinson, S.W., Kiefer, J.R., Prusakiewicz, J.J., et al., Stallings, W.C., Kurumbail, R.G., and Marnett, L.J., in 2003 in a paper entitled "A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%
B Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%
C Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%
D Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (1 - 604) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D (Q05769) response to oxidative stresssearch cyclooxygenase pathwaysearch regulation of blood pressuresearch prostaglandin biosynthetic processsearch inflammatory responsesearch oxidation-reduction processsearch prostaglandin-endoperoxide synthase activitysearch heme bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search