1pxv Summary

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The staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease

The structure was published by Filipek, R., Rzychon, M., Oleksy, A., et al., Dubin, A., Potempa, J., and Bochtler, M., in 2003 in a paper entitled "The Staphostatin-Staphopain Complex: A FORWARD BINDING INHIBITOR IN COMPLEX WITH ITS TARGET CYSTEINE PROTEASE." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cysteine protease and cysteine protease Inhibitor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cysteine protease P0C1S6 (220-393) (SSPB_STAAU)search Staphylococcus aureussearch 100% 183 100%
B cysteine protease P0C1S6 (220-393) (SSPB_STAAU)search Staphylococcus aureussearch 100% 183 100%
C cysteine protease Inhibitor Q9EYW6 (1-109) (SSPC_STAA8)search Staphylococcus aureus subsp. aureus NCTC 8325search 100% 111 100%
D cysteine protease Inhibitor Q9EYW6 (1-109) (SSPC_STAA8)search Staphylococcus aureus subsp. aureus NCTC 8325search 100% 111 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P0C1S6 (220 - 393) cysteine protease Staphylococcus aureus
Q9EYW6 (1 - 109) cysteine protease Inhibitor Staphylococcus aureus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P0C1S6) Papain-likesearch Cysteine proteinasessearch PF05543: Staphopain peptidase C47search
C, D (Q9EYW6) Staphostatinsearch Staphostatinssearch PF09023: Staphostatin Bsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P0C1S6) proteolysissearch cysteine-type peptidase activitysearch
C, D (Q9EYW6) pathogenesissearch negative regulation of peptidase activitysearch negative regulation of endopeptidase activitysearch endopeptidase inhibitor activitysearch cysteine-type endopeptidase inhibitor activitysearch peptidase inhibitor activitysearch cytoplasmsearch

Chain InterPro annotation
A, B Staphopain peptidase C47search Cysteine peptidase, histidine active sitesearch
C, D Staphostatin A/Bsearch Staphostatin Bsearch Protease inhibitor, beta-barrel domainsearch