1pxo Summary


HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine

The structure was published by Wang, S., Meades, C., Wood, G., et al., Zheleva, D., Walkinshaw, M.D., and Fischer, P.M., in 2004 in a paper entitled "2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.96 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 294 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to DNA damage stimulussearch meiotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch positive regulation of cell proliferationsearch DNA repairsearch mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch histone phosphorylationsearch potassium ion transportsearch G2/M transition of mitotic cell cyclesearch mitotic nuclear divisionsearch centrosome duplicationsearch positive regulation of transcription, DNA-templatedsearch regulation of gene silencingsearch DNA replicationsearch cellular response to nitric oxidesearch cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell divisionsearch Ras protein signal transductionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch phosphorylationsearch blood coagulationsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch histone kinase activitysearch nucleotide bindingsearch cyclin bindingsearch kinase activitysearch metal ion bindingsearch nucleoplasmsearch cytoplasmsearch cytosolsearch nucleussearch centrosomesearch microtubule organizing centersearch X chromosomesearch Cajal bodysearch endosomesearch transcription factor complexsearch Y chromosomesearch cytoskeletonsearch condensed chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch