1pxm Summary


HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol

The structure was published by Wang, S., Meades, C., Wood, G., et al., Zheleva, D., Walkinshaw, M.D., and Fischer, P.M., in 2004 in a paper entitled "2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.53 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 290 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein bindingsearch histone kinase activitysearch kinase activitysearch nucleotide bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch transferase activitysearch metal ion bindingsearch protein phosphorylationsearch positive regulation of transcription, DNA-dependentsearch regulation of gene silencingsearch meiosissearch Ras protein signal transductionsearch cell divisionsearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch response to DNA damage stimulussearch G1/S transition of mitotic cell cyclesearch cell cyclesearch mitosissearch mitotic G2 phasesearch G2/M transition of mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch blood coagulationsearch mitotic cell cyclesearch positive regulation of cell proliferationsearch centrosome duplicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch phosphorylationsearch histone phosphorylationsearch potassium ion transportsearch mitotic G1 DNA damage checkpointsearch cellular response to nitric oxidesearch nucleoplasmsearch Cajal bodysearch cytosolsearch cytoplasmsearch endosomesearch nucleussearch microtubule organizing centersearch X chromosomesearch chromosome, telomeric regionsearch transcription factor complexsearch Y chromosomesearch cytoskeletonsearch cyclin-dependent protein kinase holoenzyme complexsearch condensed chromosomesearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch