HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,5-Dichloro-thiophen-3-yl)-pyrimidin-2-ylamine
The structure was published by Wu, S.Y., McNae, I., Kontopidis, G., et al., Taylor, P., Fischer, P.M., and Walkinshaw, M.D., in 2003 in a paper entitled "Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2003.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN). The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 293 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: