1pwv Summary


Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.

The structure was published by Turk, B.E., Wong, T.Y., Schwarzenbacher, R., et al., Collier, R.J., Liddington, R.C., and Cantley, L.C., in 2004 in a paper entitled "The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.85 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Lethal factor and LF20.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Lethal factor P15917 (34-809) (LEF_BACAN)search Bacillus anthracissearch 100% 776 94%
B Lethal factor P15917 (34-809) (LEF_BACAN)search Bacillus anthracissearch 100% 776 94%
C LF20 Not available
Synthetic Not available 20 45%
D LF20 Not available
Synthetic Not available 20 45%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15917 (34 - 809) Lethal factor Bacillus anthracis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P15917) Anthrax toxin lethal factor, N- and C-terminal domainssearch, ADP-ribosylating toxinssearch Collagenase (Catalytic Domain)search, Toxin ADP-ribosyltransferase; Chain A, domain 1search, Anthrax toxin lethal factor, domain 3, chain Asearch PF07737: Anthrax toxin lethal factor, N- and C-terminal domainsearch, PF09156: Anthrax toxin lethal factor, middle domainsearch
C, D

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P15917) hydrolase activitysearch catalytic activitysearch metallopeptidase activitysearch protein bindingsearch metal ion bindingsearch peptidase activitysearch extracellular regionsearch pathogenesissearch proteolysissearch

Chain InterPro annotation
A, B Anthrax toxin, lethal/endema factorsearch Anthrax toxin, lethal/endema factor, N-/C-terminalsearch Anthrax toxin, lethal factor, centralsearch Metallopeptidase, catalytic domainsearch
C, D