1pw2 Summary

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APO STRUCTURE OF HUMAN CYCLIN-DEPENDENT KINASE 2

The structure was published by Wu, S.Y., McNae, I., Kontopidis, G., et al., Taylor, P., Fischer, P.M., and Walkinshaw, M.D., in 2003 in a paper entitled "Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 293 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 298 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch histone kinase activitysearch nucleotide bindingsearch cyclin bindingsearch transferase activitysearch metal ion bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch DNA replicationsearch Ras protein signal transductionsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of gene silencingsearch G2/M transition of mitotic cell cyclesearch phosphorylationsearch potassium ion transportsearch mitotic cell cyclesearch cellular response to DNA damage stimulussearch positive regulation of cell proliferationsearch cell cyclesearch G1/S transition of mitotic cell cyclesearch cell divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch DNA repairsearch histone phosphorylationsearch centrosome duplicationsearch meiotic cell cyclesearch meiotic nuclear divisionsearch mitotic nuclear divisionsearch blood coagulationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of transcription, DNA-templatedsearch cellular response to nitric oxidesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch nucleoplasmsearch centrosomesearch cytosolsearch nucleussearch Y chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch cytoskeletonsearch endosomesearch chromosome, telomeric regionsearch cytoplasmsearch condensed chromosomesearch X chromosomesearch transcription factor complexsearch microtubule organizing centersearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch