1pvd Summary

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CRYSTAL STRUCTURE OF THE THIAMIN DIPHOSPHATE DEPENDENT ENZYME PYRUVATE DECARBOXYLASE FROM THE YEAST SACCHAROMYCES CEREVISIAE AT 2.3 ANGSTROMS RESOLUTION

The structure was published by Arjunan, P., Umland, T., Dyda, F., et al., Gao, Y., Zhang, D., and Jordan, F., in 1996 in a paper entitled "Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1995.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PYRUVATE DECARBOXYLASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PYRUVATE DECARBOXYLASE P06169 (2-556) (PDC1_YEAST)search Saccharomyces cerevisiae S288csearch 99% 555 96%
B PYRUVATE DECARBOXYLASE P06169 (2-556) (PDC1_YEAST)search Saccharomyces cerevisiae S288csearch 99% 555 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06169 (2 - 556) PYRUVATE DECARBOXYLASE Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P06169) Pyruvate oxidase and decarboxylase, middle domainsearch, Pyruvate oxidase and decarboxylase Pyr modulesearch, Pyruvate oxidase and decarboxylase PP modulesearch Rossmann foldsearch, TPP-binding domainsearch PF00205: Thiamine pyrophosphate enzyme, central domainsearch, PF02775: Thiamine pyrophosphate enzyme, C-terminal TPP binding domainsearch, PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P06169) aromatic amino acid family catabolic process to alcohol via Ehrlich pathwaysearch amino acid catabolic process via Ehrlich pathwaysearch tryptophan catabolic processsearch pyruvate metabolic processsearch glucose catabolic process to ethanolsearch L-phenylalanine catabolic processsearch branched-chain amino acid catabolic processsearch metabolic processsearch cytoplasmsearch nucleussearch cytosolsearch thiamine pyrophosphate bindingsearch carboxy-lyase activitysearch magnesium ion bindingsearch catalytic activitysearch pyruvate decarboxylase activitysearch branched-chain-2-oxoacid decarboxylase activitysearch metal ion bindingsearch lyase activitysearch

Chain InterPro annotation
A, B TPP-binding enzyme, conserved sitesearch Thiamine pyrophosphate enzyme, C-terminal TPP-bindingsearch Thiamine pyrophosphate enzyme, central domainsearch Thiamine pyrophosphate enzyme, N-terminal TPP-binding domainsearch Thiamine pyrophosphate (TPP)-dependent enzymesearch DHS-like NAD/FAD-binding domainsearch Thiamin diphosphate-binding foldsearch