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EBI PDBe PDBeView

PDBe Entry: 1pv8 view

Crystal structure of a low activity F12L mutant of human phorphobilinogen synthase
Summary
Header lyasesearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.2 Å, R-factor: 21.0%, Free R-factor: 28.4%, Spacegroup: P 63
Released 09/09/2003, deposition: 26/06/2003, last revision: 24/02/2009
Authors Breinig, S.search; Kervinen, J.search; Stith, L.search; Wasson, A.S.search; Fairman, R.search; Wlodawer, A.search; Zdanov, A.search; Jaffe, E.K.search
Primary citation Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.
NAT.STRUCT.BIOL.search vol:10, pag:757-763 (2003) [PubMed ID 12897770 ]search
Keywords PORPHOBILINOGEN SYNTHASEsearch, TETRAPYRROLE BIOSYNTHESISsearch, REACTION INTERMEDIATEsearch, lyasesearch
EC 4.2.1.24 ExPASy BRENDA search (A B)
Organism Homo sapiens(human) 9606search(A B)
UniProt Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) (ALADH) (Porphobilinogen synthase) P13716search (A B)
Solvent A, B
Polymers
Id Name Type UniProt Residues Observed
A, B Delta-aminolevulinic acid dehydratase Protein P13716 (HEM2_HUMAN)search
 330 84%
Heterogens
Id Name Ligands
A, B ZINC ION ZN search
A 3-(2-AMINOETHYL)-4-(AMINOMETHYL)HEPTANEDIOIC ACID PB1 search
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