 |
PDBe Entry: 1ptw 
The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis
 |
HYDROLASE
|
|
X-RAY DIFFRACTION
|
|
Resolution: 2.3 Å, R-factor: 22.9%, Free R-factor: 27.4%, Spacegroup: P 21 21 21
|
|
11/11/2003, deposition: 23/06/2003, last revision: 24/02/2009
|
|
Huai, Q.; Colicelli, J.; Ke, H.
|
The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis
BIOCHEMISTRY vol:42, pag:13220-13226 (2003) [PubMed ID 14609333 ]
|
|
catalytic mechanism, cAMP hydrolysis crystal structure, binuclear catalysis, HYDROLASE
|
|
3.1.4.17 ExPASy BRENDA (A B C D)
|
|
Homo sapiens(human) 9606(A B C D)
|
|
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43) Q08499 (A B C D)
|
|
A, B, C, D
|
| A, B, C, D |
cAMP-specific phosphodiesterase PDE4D2 |
Protein |
Q08499 (PDE4D_HUMAN)
|
360 |
92% |
|
| A, B, C, D |
ZINC ION |
ZN
|
| A, B, C, D |
ADENOSINE MONOPHOSPHATE |
AMP
|
|
|
