1pth Summary

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The Structural Basis of Aspirin Activity Inferred from the Crystal Structure of Inactivated Prostaglandin H2 Synthase

The structure was published by Loll, P.J., Picot, D., and Garavito, R.M., in 1995 in a paper entitled "The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.4 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PROSTAGLANDIN H2 SYNTHASE-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROSTAGLANDIN H2 SYNTHASE-1 P05979 (25-600) (PGH1_SHEEP)search Ovis ariessearch 96% 576 95%
B PROSTAGLANDIN H2 SYNTHASE-1 P05979 (25-600) (PGH1_SHEEP)search Ovis ariessearch 96% 576 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (25 - 600) PROSTAGLANDIN H2 SYNTHASE-1 Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P05979) response to oxidative stresssearch prostaglandin biosynthetic processsearch prostaglandin metabolic processsearch inflammatory responsesearch oxidation-reduction processsearch cyclooxygenase pathwaysearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch regulation of blood pressuresearch lipid metabolic processsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch heme bindingsearch oxidoreductase activitysearch dioxygenase activitysearch metal ion bindingsearch endoplasmic reticulumsearch cytoplasmsearch membranesearch intracellular membrane-bounded organellesearch integral component of membranesearch nucleussearch endoplasmic reticulum membranesearch organelle membranesearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search