› 1psi

X-ray diffraction
2.92Å resolution

Intact recombined alpha1-antitrypsin mutant PHE 51 to LEU

Released:
DOI: 10.2210/pdb1psi/pdb
PDB entry 1psi coloured by chain, front view.
PDB entry 1psi coloured by chain, side view.
PDB entry 1psi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Elliott PR, Lomas DA, Carrell RW, Abrahams JP
Nat Struct Biol 3 676-81 (1996)
PMID: 8756325

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01009 (Residues: 26-418; Coverage: 100%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SCS 1 x SCS

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-11
Spacegroup: C2
Unit cell:
a: 112.958Å b: 38.508Å c: 88.928Å
α: 90° β: 104.85° γ: 90°
R-values:
R R work R free
0.218 0.218 0.288
Expression system: Escherichia coli

Quick links

Citations

37 review citations

Conformational disease.
Carrell et al. (1997)
36 more

3 mentions without citation

Viral subversion of apoptotic enzymes: escape from death row.
Best SM. (2008)
2 more