1psb Summary

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Solution structure of calcium loaded S100B complexed to a peptide from N-Terminal regulatory domain of NDR kinase.

The structure was published by Bhattacharya, S., Large, E., Heizmann, C.W., Hemmings, B., and Chazin, W.J., in 2003 in a paper entitled "Structure of the Ca(2+)/S100B/NDR Kinase Peptide Complex: Insights into S100 Target Specificity and Activation of the Kinase." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely S-100 protein, beta chain and Ndr Ser/Thr kinase-like protein.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S-100 protein, beta chain P02638 (2-92) (S100B_BOVIN)search Bos taurussearch 96% 91 100%
B S-100 protein, beta chain P02638 (2-92) (S100B_BOVIN)search Bos taurussearch 96% 91 100%
C Ndr Ser/Thr kinase-like protein Q15208 (62-87) (STK38_HUMAN)search Homo sapienssearch < 90% 26 100%
D Ndr Ser/Thr kinase-like protein Q15208 (62-87) (STK38_HUMAN)search Homo sapienssearch < 90% 26 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P02638 (2 - 92) S-100 protein, beta chain Bos taurus
Q15208 (62 - 87) Ndr Ser/Thr kinase-like protein

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P02638) S100 proteinssearch EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch
C, D

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P02638) calcium ion bindingsearch metal ion bindingsearch protein bindingsearch calcium-dependent protein bindingsearch zinc ion bindingsearch kinase inhibitor activitysearch S100 protein bindingsearch protein homodimerization activitysearch tau protein bindingsearch identical protein bindingsearch RAGE receptor bindingsearch cytoplasmsearch nucleussearch perinuclear region of cytoplasmsearch rufflesearch neuronal cell bodysearch intracellular membrane-bounded organellesearch learning or memorysearch memorysearch axonogenesissearch phosphorylationsearch astrocyte activationsearch regulation of neuronal synaptic plasticitysearch regulation of translationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of phosphorylationsearch positive regulation of complement activationsearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch
C, D