1ps9 Summary

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The Crystal Structure and Reaction Mechanism of E. coli 2,4-Dienoyl CoA Reductase

The structure was published by Hubbard, P.A., Liang, X., Schulz, H., and Kim, J.J., in 2003 in a paper entitled "The crystal structure and reaction mechanism of Escherichia coli 2,4-dienoyl-CoA reductase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 2,4-dienoyl-CoA reductase. This molecule has the UniProt identifier P42593 (FADH_ECOLI)search. The sample contained 671 residues which is 100% of the natural sequence. Out of 671 residues 671 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 2,4-dienoyl-CoA reductase P42593 (2-672) (FADH_ECOLI)search Escherichia coli K-12search 100% 671 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42593 (2 - 672) 2,4-dienoyl-CoA reductase Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P42593) FMN-linked oxidoreductasessearch, C-terminal domain of adrenodoxin reductase-likesearch, N-terminal domain of adrenodoxin reductase-likesearch Aldolase class Isearch, NAD(P)-binding Rossmann-like Domainsearch, FAD/NAD(P)-binding domainsearch PF00724: NADH:flavin oxidoreductase / NADH oxidase familysearch, PF07992: Pyridine nucleotide-disulphide oxidoreductasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P42593) oxidation-reduction processsearch oxidoreductase activitysearch FMN bindingsearch catalytic activitysearch 2,4-dienoyl-CoA reductase (NADPH) activitysearch metal ion bindingsearch iron-sulfur cluster bindingsearch 4 iron, 4 sulfur cluster bindingsearch

Chain InterPro annotation
A NADH:flavin oxidoreductase/NADH oxidase, N-terminalsearch FAD-dependent pyridine nucleotide-disulphide oxidoreductasesearch Aldolase-type TIM barrelsearch Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domainsearch