1prh Summary

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THE X-RAY CRYSTAL STRUCTURE OF THE MEMBRANE PROTEIN PROSTAGLANDIN H2 SYNTHASE-1

The structure was published by Picot, D., Loll, P.J., and Garavito, R.M., in 1994 in a paper entitled "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PROSTAGLANDIN H2 SYNTHASE-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROSTAGLANDIN H2 SYNTHASE-1 P05979 (33-586) (PGH1_SHEEP)search Ovis ariessearch 96% 554 100%
B PROSTAGLANDIN H2 SYNTHASE-1 P05979 (33-586) (PGH1_SHEEP)search Ovis ariessearch 96% 554 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (33 - 586) PROSTAGLANDIN H2 SYNTHASE-1 Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P05979) prostaglandin biosynthetic processsearch oxidation-reduction processsearch response to oxidative stresssearch regulation of blood pressuresearch fatty acid biosynthetic processsearch lipid metabolic processsearch prostaglandin metabolic processsearch fatty acid metabolic processsearch oxidoreductase activitysearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch integral to membranesearch endoplasmic reticulumsearch intracellular membrane-bounded organellesearch endoplasmic reticulum membranesearch cytoplasmsearch membranesearch nucleussearch organelle membranesearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidase, animalsearch Haem peroxidasesearch Haem peroxidase, animal, subgroupsearch