1prg Summary

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LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA

The structure was published by Nolte, R.T., Wisely, G.B., Westin, S., et al., Willson, T.M., Glass, C.K., and Milburn, M.V., in 1998 in a paper entitled "Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA).

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA) P37231 (235-504) (PPARG_HUMAN)search Homo sapienssearch < 90% 270 100%
B PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA) P37231 (235-504) (PPARG_HUMAN)search Homo sapienssearch < 90% 270 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37231 (235 - 504) PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P37231) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch