1pqc Summary

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HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317

The structure was published by Farnegardh, M., Bonn, T., Sun, S., et al., Wilhelmsson, A., Gustafsson, J.-A., and Carlquist, M., in 2003 in a paper entitled "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Oxysterols receptor LXR-beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Oxysterols receptor LXR-beta P55055 (212-460) (NR1H2_HUMAN)search Homo sapienssearch < 90% 253 94%
B Oxysterols receptor LXR-beta P55055 (212-460) (NR1H2_HUMAN)search Homo sapienssearch < 90% 253 94%
C Oxysterols receptor LXR-beta P55055 (212-460) (NR1H2_HUMAN)search Homo sapienssearch < 90% 253 94%
D Oxysterols receptor LXR-beta P55055 (212-460) (NR1H2_HUMAN)search Homo sapienssearch < 90% 253 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P55055 (212 - 460) Oxysterols receptor LXR-beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P55055) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A, B, C, D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch Liver X receptorsearch