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Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold.

Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA
Structure 12 145-56 (2004)
Cited: 14 times
EuropePMC logo PMID: 14725774

Abstract

Superantigens are a class of microbial proteins with the ability to excessively activate T cells by binding to the T cell receptor. The staphylococcal and streptococcal superantigens are closely related in structure and possess an N-terminal domain that resembles an OB fold and a C-terminal domain similar to a beta-grasp fold. Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other proteins. We have determined the crystal and solution structures of YPMa, which show that the protein has a jelly-roll fold. The closest structural neighbors to YPMa are viral capsid proteins and members of the tumor necrosis factor superfamily. In the crystal structure, YPMa packs as a trimer, another feature shared with viral capsid proteins and TNF superfamily proteins. However, in solution YPMa behaves as a monomer, and any functional relevance of the trimer observed in the crystals is yet to be established.

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  1. pKNOT: the protein KNOT web server. Lai YL, Yen SC, Yu SH, Hwang JK. Nucleic Acids Res 35 W420-4 (2007)


Reviews citing this publication (5)

  1. Macromolecular NMR spectroscopy for the non-spectroscopist. Kwan AH, Mobli M, Gooley PR, King GF, Mackay JP. FEBS J 278 687-703 (2011)
  2. Toxins from bacteria. Henkel JS, Baldwin MR, Barbieri JT. EXS 100 1-29 (2010)
  3. Size does matter! Label-free detection of small molecule-protein interaction. Fechner P, Bleher O, Ewald M, Freudenberger K, Furin D, Hilbig U, Kolarov F, Krieg K, Leidner L, Markovic G, Proll G, Pröll F, Rau S, Riedt J, Schwarz B, Weber P, Widmaier J. Anal Bioanal Chem 406 4033-4051 (2014)
  4. Whaddaya Know: A Guide to Uncertainty and Subjectivity in Structural Biology. Mackay JP, Landsberg MJ, Whitten AE, Bond CS. Trends Biochem Sci 42 155-167 (2017)
  5. Novel insights into the immune response to bacterial T cell superantigens. Tuffs SW, Dufresne K, Rishi A, Walton NR, McCormick JK. Nat Rev Immunol (2024)

Articles citing this publication (8)

  1. Structure and calcium-binding activity of LipL32, the major surface antigen of pathogenic Leptospira sp. Hauk P, Guzzo CR, Roman Ramos H, Ho PL, Farah CS. J Mol Biol 390 722-736 (2009)
  2. Viral capsid proteins are segregated in structural fold space. Cheng S, Brooks CL. PLoS Comput Biol 9 e1002905 (2013)
  3. Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA. De Marzí MC, Fernández MM, Sundberg EJ, Molinero L, Zwirner NW, Llera AS, Mariuzza RA, Malchiodi EL. Eur J Biochem 271 4075-4083 (2004)
  4. Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells. Goubard A, Loïez C, Abe J, Fichel C, Herwegh S, Faveeuw C, Porte R, Cayet D, Sebbane F, Penet S, Foligné B, Desreumaux P, Saito H, Sirard JC, Simonet M, Carnoy C. Infect Immun 83 2053-2064 (2015)
  5. Mutagenesis, biochemical, and biophysical characterization of Mycoplasma arthritidis-derived mitogen. Li H, Zhao Y, Guo Y, Vanvranken SJ, Li Z, Eisele L, Mourad W. Mol Immunol 44 763-773 (2007)
  6. Pfit is a structurally novel Crohn's disease-associated superantigen. Liu L, Chen H, Brecher MB, Li Z, Wei B, Nandi B, Zhang J, Ling H, Winslow G, Braun J, Li H. PLoS Pathog 9 e1003837 (2013)
  7. Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer. Liu L, Li Z, Guo Y, VanVranken SJ, Mourad W, Li H. J Mol Biol 399 367-376 (2010)
  8. Expression, purification and crystallization of Streptococcus dysgalactiae-derived mitogen. Papageorgiou AC, Saarinen S, Ramirez-Bartutis R, Kato H, Uchiyama T, Kirikae T, Miyoshi-Akiyama T. Acta Crystallogr Sect F Struct Biol Cryst Commun 62 242-244 (2006)


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