1pnl Summary

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PENICILLIN ACYLASE HAS A SINGLE-AMINO-ACID CATALYTIC CENTRE

The structure was published by Duggleby, H.J., Tolley, S.P., Hill, C.P., Dodson, E.J., Dodson, G., and Moody, P.C., in 1995 in a paper entitled "Penicillin acylase has a single-amino-acid catalytic centre." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PENICILLIN AMIDOHYDROLASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PENICILLIN AMIDOHYDROLASE P06875 (27-235) (PAC_ECOLX)search Escherichia colisearch < 90% 209 92%
B PENICILLIN AMIDOHYDROLASE P06875 (290-846) (PAC_ECOLX)search Escherichia colisearch < 90% 557 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06875 (27 - 235) PENICILLIN AMIDOHYDROLASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Penicillin acylase, catalytic domainsearch Penicillin Amidohydrolase, domain 1search, Helix Hairpinssearch Penicillin amidasesearch
B Penicillin acylase, catalytic domainsearch Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1search, Penicillin G acylase, beta-roll domainsearch, Penicillin amidase (Acylase) alpha subunit, N-terminal domainsearch Penicillin amidasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P06875) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidessearch hydrolase activitysearch antibiotic biosynthetic processsearch
B (P06875) hydrolase activitysearch antibiotic biosynthetic processsearch

Chain InterPro annotation
A Penicillin amidase-likesearch Penicillin amidase type, domain1search Nucleophile aminohydrolases, N-terminalsearch
B Penicillin amidase-likesearch Nucleophile aminohydrolases, N-terminalsearch