1pmm Summary

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Crystal structure of Escherichia coli GadB (low pH)

The structure was published by Capitani, G., De Biase, D., Aurizi, C., Gut, H., Bossa, F., and Grutter, M.G., in 2003 in a paper entitled "Crystal structure and functional analysis of escherichia coli glutamate decarboxylase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glutamate decarboxylase beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutamate decarboxylase beta P69910 (1-466) (DCEB_ECOLI)search Escherichia coli K-12search 97% 466 96%
B Glutamate decarboxylase beta P69910 (1-466) (DCEB_ECOLI)search Escherichia coli K-12search 97% 466 96%
C Glutamate decarboxylase beta P69910 (1-466) (DCEB_ECOLI)search Escherichia coli K-12search 97% 466 96%
D Glutamate decarboxylase beta P69910 (1-466) (DCEB_ECOLI)search Escherichia coli K-12search 97% 466 96%
E Glutamate decarboxylase beta P69910 (1-466) (DCEB_ECOLI)search Escherichia coli K-12search 97% 466 96%
F Glutamate decarboxylase beta P69910 (1-466) (DCEB_ECOLI)search Escherichia coli K-12search 97% 466 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P69910 (1 - 466) Glutamate decarboxylase beta Escherichia coli

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D, E, F (P69910) Pyridoxal-dependent decarboxylasesearch PF00282: Pyridoxal-dependent decarboxylase conserved domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D, E, F (P69910) catalytic activitysearch pyridoxal phosphate bindingsearch carboxy-lyase activitysearch glutamate decarboxylase activitysearch lyase activitysearch glutamate metabolic processsearch carboxylic acid metabolic processsearch intracellular pH elevationsearch cytosolsearch membranesearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D, E, F Pyridoxal phosphate-dependent decarboxylasesearch Glutamate decarboxylasesearch Pyridoxal phosphate-dependent transferase, major region, subdomain 1search Pyridoxal phosphate-dependent transferasesearch Pyridoxal-phosphate binding sitesearch