1pme Summary

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STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE

The structure was published by Fox, T., Coll, J.T., Xie, X., et al., Galullo, V., Su, M.S., and Wilson, K.P., in 1998 in a paper entitled "A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ERK2. This molecule has the UniProt identifier P28482 (MK01_HUMAN)search. The sample contained 380 residues which is 100% of the natural sequence. Out of 380 residues 333 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ERK2 P28482 (1-360) (MK01_HUMAN)search Homo sapienssearch 97% 380 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28482 (1 - 360) ERK2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P28482) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P28482) protein serine/threonine kinase activitysearch protein bindingsearch transferase activitysearch MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch phosphotyrosine bindingsearch kinase activitysearch mitogen-activated protein kinase kinase kinase bindingsearch transcription factor bindingsearch RNA polymerase II carboxy-terminal domain kinase activitysearch nucleotide bindingsearch phosphatase bindingsearch DNA bindingsearch cytosolsearch mitochondrionsearch perikaryonsearch microtubule organizing centersearch dendrite cytoplasmsearch nucleoplasmsearch nucleussearch caveolasearch mitotic spindlesearch pseudopodiumsearch nucleolussearch Golgi apparatussearch cytoskeletonsearch spindlesearch focal adhesionsearch cytoplasmsearch microtubule cytoskeletonsearch extracellular vesicular exosomesearch protein complexsearch early endosomesearch late endosomesearch organ morphogenesissearch axon guidancesearch toll-like receptor 5 signaling pathwaysearch activation of MAPK activitysearch Fc-gamma receptor signaling pathway involved in phagocytosissearch chemotaxissearch MAPK cascadesearch phosphorylationsearch MyD88-dependent toll-like receptor signaling pathwaysearch caveolin-mediated endocytosissearch ERBB signaling pathwaysearch small GTPase mediated signal transductionsearch peptidyl-threonine phosphorylationsearch TRIF-dependent toll-like receptor signaling pathwaysearch signal transductionsearch protein phosphorylationsearch transcription, DNA-templatedsearch viral processsearch positive regulation of translationsearch response to epidermal growth factorsearch mammary gland epithelial cell proliferationsearch MAPK import into nucleussearch Ras protein signal transductionsearch peptidyl-serine phosphorylationsearch response to exogenous dsRNAsearch cellular response to granulocyte macrophage colony-stimulating factor stimulussearch ERK1 and ERK2 cascadesearch toll-like receptor 10 signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch insulin receptor signaling pathwaysearch intracellular signal transductionsearch Fc-epsilon receptor signaling pathwaysearch B cell receptor signaling pathwaysearch sensory perception of painsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of transcription, DNA-templatedsearch JAK-STAT cascade involved in growth hormone signaling pathwaysearch cytosine metabolic processsearch synaptic transmissionsearch toll-like receptor signaling pathwaysearch cellular response to DNA damage stimulussearch lipopolysaccharide-mediated signaling pathwaysearch fibroblast growth factor receptor signaling pathwaysearch response to estrogensearch labyrinthine layer blood vessel developmentsearch platelet activationsearch regulation of transcription, DNA-templatedsearch regulation of stress-activated MAPK cascadesearch regulation of Golgi inheritancesearch apoptotic processsearch neurotrophin TRK receptor signaling pathwaysearch innate immune responsesearch stress-activated MAPK cascadesearch regulation of cytoskeleton organizationsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of peptidyl-threonine phosphorylationsearch blood coagulationsearch toll-like receptor 4 signaling pathwaysearch positive regulation of cell proliferationsearch response to stresssearch regulation of protein stabilitysearch toll-like receptor 9 signaling pathwaysearch response to toxic substancesearch T cell receptor signaling pathwaysearch cell cyclesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch regulation of early endosome to late endosome transportsearch positive regulation of cell migrationsearch negative regulation of cell differentiationsearch epidermal growth factor receptor signaling pathwaysearch activation of MAPKK activitysearch response to lipopolysaccharidesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch