1pkw Summary


Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione

The structure was published by Grahn, E., Novotny, M., Jakobsson, E., et al., Wahlberg, M., Mannervik, B., and Kleywegt, G.J., in 2006 in a paper entitled "New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glutathione S-transferase A1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutathione S-transferase A1 P08263 (1-222) (GSTA1_HUMAN)search Homo sapienssearch 98% 222 99%
B Glutathione S-transferase A1 P08263 (1-222) (GSTA1_HUMAN)search Homo sapienssearch 98% 222 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08263 (1 - 222) Glutathione S-transferase A1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P08263) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P08263) xenobiotic metabolic processsearch metabolic processsearch epithelial cell differentiationsearch small molecule metabolic processsearch glutathione derivative biosynthetic processsearch glutathione metabolic processsearch glutathione transferase activitysearch transferase activitysearch extracellular exosomesearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A, B Glutathione S-transferase, alpha classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch