1pkw Summary

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Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione

The structure was published by Grahn, E., Novotny, M., Jakobsson, E., et al., Wahlberg, M., Mannervik, B., and Kleywegt, G.J., in 2006 in a paper entitled "New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glutathione S-transferase A1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutathione S-transferase A1 P08263 (1-222) (GSTA1_HUMAN)search Homo sapienssearch 98% 222 99%
B Glutathione S-transferase A1 P08263 (1-222) (GSTA1_HUMAN)search Homo sapienssearch 98% 222 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08263 (1 - 222) Glutathione S-transferase A1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P08263) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P08263) metabolic processsearch small molecule metabolic processsearch glutathione derivative biosynthetic processsearch glutathione metabolic processsearch xenobiotic metabolic processsearch glutathione transferase activitysearch transferase activitysearch cytoplasmsearch cytosolsearch

Chain InterPro annotation
A, B Glutathione S-transferase, alpha classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch search