1pkt Summary

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STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY

The structure was published by Koyama, S., Yu, H., Dalgarno, D.C., Shin, T.B., Zydowsky, L.D., and Schreiber, S.L., in 1993 in a paper entitled "Structure of the PI3K SH3 domain and analysis of the SH3 family." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN. This molecule has the UniProt identifier P27986 (P85A_HUMAN)search. The sample contained 79 residues which is < 90% of the natural sequence. Out of 79 residues 76 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN P27986 (1-79) (P85A_HUMAN)search Homo sapienssearch < 90% 79 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27986 (1 - 79) PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch Variant SH3 domainsearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P27986) phosphatidylinositol 3-kinase complexsearch phosphatidylinositol 3-kinase regulator activitysearch

Chain InterPro annotation
A SH3 domainsearch PI3 kinase, P85 regulatory subunitsearch Variant SH3 domainsearch