1pkn Summary



The structure was published by Larsen, T.M., Laughlin, L.T., Holden, H.M., Rayment, I., and Reed, G.H., in 1994 in a paper entitled "Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PYRUVATE KINASE. This molecule has the UniProt identifier P11974 (KPYM_RABIT)search. The sample contained 530 residues which is 100% of the natural sequence. Out of 530 residues 513 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PYRUVATE KINASE P11974 (2-531) (KPYM_RABIT)search Oryctolagus cuniculussearch 100% 530 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11974 (2 - 531) PYRUVATE KINASE Oryctolagus cuniculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P11974) Pyruvate kinase beta-barrel domainsearch, Pyruvate kinasesearch, Pyruvate kinase, C-terminal domainsearch Pyruvate Kinase; Chain: A, domain 1search, Phosphoenolpyruvate-binding domainssearch, M1 Pyruvate Kinase; Domain 3search PF00224: Pyruvate kinase, barrel domainsearch, PF02887: Pyruvate kinase, alpha/beta domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P11974) glycolytic processsearch metabolic processsearch phosphorylationsearch potassium ion bindingsearch catalytic activitysearch pyruvate kinase activitysearch magnesium ion bindingsearch metal ion bindingsearch transferase activitysearch nucleotide bindingsearch protein bindingsearch ATP bindingsearch kinase activitysearch nucleussearch cytoplasmsearch

Chain InterPro annotation
A Pyruvate kinasesearch Pyruvate kinase-like, insert domainsearch Pyruvate kinase, barrelsearch Pyruvate kinase, alpha/betasearch Pyruvate kinase, C-terminalsearch Pyruvate kinase, beta-barrel insert domainsearch Pyruvate/Phosphoenolpyruvate kinase-like domainsearch Pyruvate kinase, active sitesearch