1pkg Summary


Structure of a c-Kit Kinase Product Complex

The structure was published by Mol, C.D., Lim, K.B., Sridhar, V., et al., Kassel, D.B., Cronin, C.N., and McRee, D.E., in 2003 in a paper entitled "Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of c-kit protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A c-kit protein P10721 (549-693) (KIT_HUMAN)search ,
P10721 (754-935) (KIT_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
329 88%
B c-kit protein P10721 (549-935) (KIT_HUMAN)search Homo sapienssearch < 90% 329 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10721 (549 - 693) c-kit protein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P10721) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch membranesearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch