1pk5 Summary

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Crystal structure of the orphan nuclear receptor LRH-1

The structure was published by Sablin, E.P., Krylova, I.N., Fletterick, R.J., and Ingraham, H.A., in 2003 in a paper entitled "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Orphan nuclear receptor NR5A2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Orphan nuclear receptor NR5A2 P45448 (313-560) (NR5A2_MOUSE)search Mus musculussearch < 90% 248 97%
B Orphan nuclear receptor NR5A2 P45448 (313-560) (NR5A2_MOUSE)search Mus musculussearch < 90% 248 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P45448 (313 - 560) Orphan nuclear receptor NR5A2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P45448) steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch