1pjq Summary

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Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis

The structure was published by Stroupe, M.E., Leech, H.K., Daniels, D.S., Warren, M.J., and Getzoff, E.D., in 2003 in a paper entitled "CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.21 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Siroheme synthase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Siroheme synthase P25924 (1-457) (CYSG_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 457 99%
B Siroheme synthase P25924 (1-457) (CYSG_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 457 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P25924 (1 - 457) Siroheme synthase Salmonella enterica subsp. enterica serovar Typhimurium

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P25924) Siroheme synthase N-terminal domain-likesearch, Tetrapyrrole methylasesearch, Siroheme synthase middle domains-likesearch NAD(P)-binding Rossmann-like Domainsearch, Siroheme synthase; domain 2search, multifunctional methyltransferase/dehydrogenase/ferrochelatase, domain 3search, Cobalt-precorrin-4 Transmethylase; Domain 1search, Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2search PF00590: Tetrapyrrole (Corrin/Porphyrin) Methylasessearch, PF10414: Sirohaem synthase dimerisation regionsearch, PF13241: Putative NAD(P)-bindingsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P25924) methyltransferase activitysearch precorrin-2 dehydrogenase activitysearch uroporphyrin-III C-methyltransferase activitysearch sirohydrochlorin ferrochelatase activitysearch NAD bindingsearch lyase activitysearch ferrochelatase activitysearch oxidoreductase activitysearch transferase activitysearch catalytic activitysearch oxidation-reduction processsearch cobalamin biosynthetic processsearch porphyrin-containing compound biosynthetic processsearch siroheme biosynthetic processsearch metabolic processsearch methylationsearch

Chain InterPro annotation
A, B Tetrapyrrole methylasesearch Uroporphiryn-III C-methyltransferase, conserved sitesearch Uroporphyrin-III C-methyltransferasesearch Sirohaem synthase, N-terminalsearch Sirohaem synthasesearch Tetrapyrrole methylase, subdomain 2search Tetrapyrrole methylase, subdomain 1search NAD(P)-binding domainsearch Sirohaem synthase, dimerisation domainsearch