1pii Summary

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THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION

The structure was published by Wilmanns, M., Priestle, J.P., Niermann, T., and Jansonius, J.N., in 1992 in a paper entitled "Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from Escherichia coli refined at 2.0 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of N-(5'PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE. This molecule has the UniProt identifier P00909 (TRPC_ECOLI)search. The sample contained 452 residues which is 100% of the natural sequence. Out of 452 residues 452 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A N-(5'PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE P00909 (2-453) (TRPC_ECOLI)search Escherichia coli K-12search 100% 452 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00909 (2 - 453) N-(5'PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00909) Tryptophan biosynthesis enzymessearch Aldolase class Isearch PF00218: Indole-3-glycerol phosphate synthasesearch, PF00697: N-(5'phosphoribosyl)anthranilate (PRA) isomerasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P00909) metabolic processsearch tryptophan metabolic processsearch cellular amino acid biosynthetic processsearch tryptophan biosynthetic processsearch aromatic amino acid family biosynthetic processsearch phosphoribosylanthranilate isomerase activitysearch indole-3-glycerol-phosphate synthase activitysearch catalytic activitysearch lyase activitysearch isomerase activitysearch carboxy-lyase activitysearch

Chain InterPro annotation
A N-(5'phosphoribosyl) anthranilate isomerase (PRAI) like domainsearch Indole-3-glycerol phosphate synthase, conserved sitesearch Ribulose-phosphate binding barrelsearch Aldolase-type TIM barrelsearch Indole-3-glycerol phosphate synthasesearch