1pic Summary

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PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE

The structure was published by Breeze, A.L., Kara, B.V., Barratt, D.G., et al., Luke, R.W., Best, J.R., and Cartlidge, S.A., in 1996 in a paper entitled "Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PHOSPHATIDYLINOSITOL 3-KINASE and BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL 3-KINASE P27986 (617-724) (P85A_HUMAN)search Homo sapienssearch < 90% 112 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27986 (617 - 724) PHOSPHATIDYLINOSITOL 3-KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P27986) phosphatidylinositol 3-kinase complexsearch phosphatidylinositol 3-kinase regulator activitysearch

Chain InterPro annotation
A SH2 domainsearch PI3 kinase, P85 regulatory subunitsearch