1pgt Summary

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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH S-HEXYLGLUTATHIONE

The structure was published by Ji, X., Tordova, M., O'Donnell, R., et al., Hayden, J.B., Gilliland, G.L., and Zimniak, P., in 1997 in a paper entitled "Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLUTATHIONE S-TRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTATHIONE S-TRANSFERASE P09211 (1-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 210 100%
B GLUTATHIONE S-TRANSFERASE P09211 (1-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 210 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09211 (1 - 210) GLUTATHIONE S-TRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P09211) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P09211) response to reactive oxygen speciessearch xenobiotic metabolic processsearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of acute inflammatory responsesearch negative regulation of JUN kinase activitysearch negative regulation of tumor necrosis factor productionsearch negative regulation of stress-activated MAPK cascadesearch central nervous system developmentsearch regulation of stress-activated MAPK cascadesearch negative regulation of tumor necrosis factor-mediated signaling pathwaysearch negative regulation of protein kinase activitysearch negative regulation of apoptotic processsearch negative regulation of fibroblast proliferationsearch positive regulation of superoxide anion generationsearch negative regulation of MAP kinase activitysearch negative regulation of biosynthetic processsearch glutathione derivative biosynthetic processsearch common myeloid progenitor cell proliferationsearch regulation of ERK1 and ERK2 cascadesearch negative regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of interleukin-1 beta productionsearch cellular response to lipopolysaccharidesearch nitric oxide storagesearch negative regulation of MAPK cascadesearch negative regulation of ERK1 and ERK2 cascadesearch negative regulation of leukocyte proliferationsearch glutathione metabolic processsearch negative regulation of nitric-oxide synthase biosynthetic processsearch small molecule metabolic processsearch negative regulation of monocyte chemotactic protein-1 productionsearch metabolic processsearch vesiclesearch cytosolsearch nucleussearch extracellular exosomesearch mitochondrionsearch extracellular spacesearch intracellularsearch cytoplasmsearch plasma membranesearch TRAF2-GSTP1 complexsearch transferase activitysearch protein bindingsearch glutathione transferase activitysearch kinase regulator activitysearch nitric oxide bindingsearch dinitrosyl-iron complex bindingsearch S-nitrosoglutathione bindingsearch JUN kinase bindingsearch

Chain InterPro annotation
A, B Glutathione S-transferase, Pi classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch