1pgf Summary

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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL

The structure was published by Loll, P.J., Picot, D., Ekabo, O., and Garavito, R.M., in 1996 in a paper entitled "Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.5 Å and deposited in 1995.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROSTAGLANDIN H2 SYNTHASE-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROSTAGLANDIN H2 SYNTHASE-1 P05979 (25-600) (PGH1_SHEEP)search Ovis ariessearch 96% 576 95%
B PROSTAGLANDIN H2 SYNTHASE-1 P05979 (25-600) (PGH1_SHEEP)search Ovis ariessearch 96% 576 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (25 - 600) PROSTAGLANDIN H2 SYNTHASE-1 Ovis aries

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch PF03098: Animal haem peroxidasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P05979) organelle membranesearch endoplasmic reticulum membranesearch membranesearch cytoplasmsearch intracellular membrane-bounded organellesearch integral component of membranesearch endoplasmic reticulumsearch nucleussearch oxidoreductase activitysearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch metal ion bindingsearch heme bindingsearch fatty acid biosynthetic processsearch regulation of blood pressuresearch oxidation-reduction processsearch response to oxidative stresssearch inflammatory responsesearch prostaglandin biosynthetic processsearch cyclooxygenase pathwaysearch fatty acid metabolic processsearch prostaglandin metabolic processsearch lipid metabolic processsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search