1pfx Summary



There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Brandstetter, H., Bauer, M., Huber, R., Lollar, P., and Bode, W., in 1995 in a paper entitled "X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely FACTOR IXA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C FACTOR IXA P16293 (183-409) (FA9_PIG)search Sus scrofasearch < 90% 235 100%
L FACTOR IXA P16293 (8-147) (FA9_PIG)search Sus scrofasearch < 90% 146 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16293 (183 - 409) FACTOR IXA Sus scrofa

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C Eukaryotic proteasessearch Trypsin-like serine proteasessearch Trypsinsearch
L GLA-domainsearch, EGF-type modulesearch Coagulation Factor IXsearch, Lamininsearch EGF-like domainsearch, Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domainsearch, Coagulation Factor Xa inhibitory sitesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
C (P16293) catalytic activitysearch serine-type endopeptidase activitysearch proteolysissearch
L (P16293) calcium ion bindingsearch extracellular regionsearch

Chain InterPro annotation
C Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
L EGF-type aspartate/asparagine hydroxylation sitesearch Gamma-carboxyglutamic acid-rich (GLA) domainsearch Epidermal growth factor-like domainsearch EGF-like calcium-binding domainsearch EGF-like, conserved sitesearch Coagulation factor, subgroup, Gla domainsearch EGF-like calcium-binding, conserved sitesearch