› 1pfq

X-ray diffraction
1.9Å resolution

crystal structure of human apo dipeptidyl peptidase IV / CD26

Released:
DOI: 10.2210/pdb1pfq/pdb
PDB entry 1pfq coloured by chain, front view.
PDB entry 1pfq coloured by chain, side view.
PDB entry 1pfq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Oefner C, D'Arcy A, Mac Sweeney A, Pierau S, Gardiner R, Dale GE
Acta Crystallogr D Biol Crystallogr 59 1206-12 (2003)
PMID: 12832764

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 731 amino acids
Theoretical weight: 84.75 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P27487 (Residues: 36-766; Coverage: 95%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 71.031Å b: 118.142Å c: 184.583Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.254 0.298
Expression system: Komagataella pastoris

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Citations

12 review citations

Chemistry and biology of multicomponent reactions.
Dömling et al. (2012)
11 more

8 mentions without citation

Human cell receptors: potential drug targets to combat COVID-19.
Raghav et al. (2021)
7 more