1pf8 Summary


Crystal Structure of Human Cyclin-Dependent Kinase 2 Complexed with a Nucleoside Inhibitor

The structure was published by Moshinsky, D.J., Bellamacina, C.R., Boisvert, D.C., et al., Jancarik, J., Kim, S.H., and Rice, A.G., in 2003 in a paper entitled "SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.51 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 297 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch protein kinase activitysearch protein serine/threonine kinase activitysearch histone kinase activitysearch transferase activitysearch cyclin bindingsearch metal ion bindingsearch nucleotide bindingsearch protein phosphorylationsearch G2/M transition of mitotic cell cyclesearch centrosome duplicationsearch histone phosphorylationsearch positive regulation of DNA-dependent DNA replication initiationsearch cell cyclesearch Ras protein signal transductionsearch G1/S transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic cell cyclesearch potassium ion transportsearch DNA replicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to DNA damage stimulussearch mitotic G1 DNA damage checkpointsearch positive regulation of transcription, DNA-templatedsearch meiotic nuclear divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell divisionsearch blood coagulationsearch DNA repairsearch mitotic nuclear divisionsearch regulation of gene silencingsearch phosphorylationsearch cellular response to nitric oxidesearch nucleoplasmsearch cytoskeletonsearch cytoplasmsearch Y chromosomesearch Cajal bodysearch X chromosomesearch microtubule organizing centersearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch centrosomesearch endosomesearch condensed chromosomesearch chromosome, telomeric regionsearch transcription factor complexsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch