1pdu Summary


Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

The structure was published by Baker, K.D., Shewchuk, L.M., Korlova, T., et al., Thummel, C.S., Wilson, T.M., and Mangelsdorf, D.J., in 2003 in a paper entitled "The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of nuclear hormone receptor HR38.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A nuclear hormone receptor HR38 P49869 (842-1073) (HR38_DROME)search Drosophila melanogastersearch < 90% 244 94%
B nuclear hormone receptor HR38 P49869 (842-1073) (HR38_DROME)search Drosophila melanogastersearch < 90% 244 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49869 (842 - 1073) nuclear hormone receptor HR38 Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P49869) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Orphan nuclear receptorsearch Nuclear hormone receptor, ligand-bindingsearch