1pae Summary


nucleoside diphosphate kinase

The structure was published by Strub, M.-P., Hoh, F., Sanchez, J.-F., et al., Bock, A., Aumelas, A., and Dumas, C., in 2003 in a paper entitled "Selenomethionine and Selenocysteine Double Labeling Strategy for Crystallographic Phasing" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Nucleoside diphosphate kinase, cytosolic. This molecule has the UniProt identifier P22887 (NDKC_DICDI)search. The sample contained 155 residues which is 100% of the natural sequence. Out of 155 residues 147 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Nucleoside diphosphate kinase, cytosolic P22887 (1-155) (NDKC_DICDI)search Dictyostelium discoideumsearch 97% 155 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22887 (1 - 155) Nucleoside diphosphate kinase, cytosolic Dictyostelium discoideum

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
X (P22887) Nucleoside diphosphate kinase, NDKsearch Alpha-Beta Plaitssearch PF00334: Nucleoside diphosphate kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
X (P22887) kinase activitysearch nucleoside diphosphate kinase activitysearch ATP bindingsearch metal ion bindingsearch nucleotide bindingsearch transferase activitysearch response to bacteriumsearch negative regulation of pinocytosissearch actin cytoskeleton organizationsearch cell growthsearch nucleoside triphosphate biosynthetic processsearch GTP biosynthetic processsearch negative regulation of exocytosissearch negative regulation of phagocytosissearch G-protein coupled receptor signaling pathwaysearch translational elongationsearch dGDP phosphorylationsearch nucleoside diphosphate phosphorylationsearch CTP biosynthetic processsearch nucleotide metabolic processsearch macropinocytosissearch UTP biosynthetic processsearch dGTP biosynthetic process from dGDPsearch phosphorylationsearch secretory granulesearch cytoplasmsearch ribosomesearch actin cytoskeletonsearch phagocytic vesiclesearch plasma membranesearch cytoskeletonsearch

Chain InterPro annotation
X Nucleoside diphosphate kinasesearch