EC 2.7.4.6: Nucleoside-diphosphate kinase
Reaction catalysed:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Systematic name:
ATP:nucleoside-diphosphate phosphotransferase
Alternative Name(s):
- NDK
- Nucleoside 5'-diphosphate kinase
- Nucleoside 5'-diphosphate phosphotransferase
- Nucleoside diphosphate (UDP) kinase
- Nucleoside diphosphokinase
- Nucleotide phosphate kinase
- UDP kinase
- Uridine diphosphate kinase
GO terms
Biochemical function:
Biological process:
- negative regulation of phagocytosis
- negative regulation of pinocytosis
- negative regulation of exocytosis
- actin cytoskeleton organization
- asexual reproduction
- response to bacterium
- nucleoside triphosphate biosynthetic process
- nucleotide metabolic process
- G protein-coupled receptor signaling pathway
- translational elongation
- CTP biosynthetic process
- UTP biosynthetic process
- dGTP biosynthetic process from dGDP
- GTP biosynthetic process
Protein family (Pfam)![The deposited structure of PDB entry 1pae contains 1 copy of Pfam domain PF00334 (Nucleoside diphosphate kinase) in Nucleoside diphosphate kinase, cytosolic. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/1pae_1_X_Pfam_PF00334_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1pae</span> contains 1 copy of Pfam domain <span class='highlight'>PF00334 (Nucleoside diphosphate kinase)</span> in <span class='highlight'>Nucleoside diphosphate kinase, cytosolic</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 1pae contains 1 copy of CATH domain 3.30.70.141 (Alpha-Beta Plaits) in Nucleoside diphosphate kinase, cytosolic. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/1pae_1_X_CATH_3.30.70.141_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1pae</span> contains 1 copy of CATH domain <span class='highlight'>3.30.70.141 (Alpha-Beta Plaits)</span> in <span class='highlight'>Nucleoside diphosphate kinase, cytosolic</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")
SCOP annotation![The deposited structure of PDB entry 1pae contains 1 copy of SCOP domain 54920 (Nucleoside diphosphate kinase, NDK) in Nucleoside diphosphate kinase, cytosolic. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/1pae_1_X_SCOP_54920_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1pae</span> contains 1 copy of SCOP domain <span class='highlight'>54920 (Nucleoside diphosphate kinase, NDK)</span> in <span class='highlight'>Nucleoside diphosphate kinase, cytosolic</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")